{"id":7722,"date":"2024-02-15T18:18:28","date_gmt":"2024-02-15T17:18:28","guid":{"rendered":"https:\/\/genetika-plzen.nullable.group\/?page_id=7722"},"modified":"2024-02-15T18:37:31","modified_gmt":"2024-02-15T17:37:31","slug":"pgt-a-preimplantacni-geneticke-testovani-aneuploidii","status":"publish","type":"page","link":"https:\/\/genetika-plzen.nullable.group\/en\/vysetreni-reprodukcni-genetiky\/pgt-a-preimplantacni-geneticke-testovani-aneuploidii\/","title":{"rendered":"Preimplantation Genetic Testing for Aneuploidies"},"content":{"rendered":"
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Former name PGS: Preimplantation Genetic Screening<\/h2>\n\n

Preimplantation genetic screening (PGS (PGT-A)) is a test focused on the chromosomal makeup of the embryo. It is known that one of the main causes of infertility in humans is the formation of embryos with an abnormal chromosomal set. Such embryos either do not lead to pregnancy at all (do not implant into the uterine lining) or lead to miscarriages or, in extreme cases, the birth of a child with disabilities.<\/p>\n\n

With PGS (PGT-A), it is possible to distinguish embryos with a normal chromosomal finding from embryos with sporadic (i.e., de novo, non-inherited) deviations in the number of whole chromosomes or their parts (with so-called aneuploidies). \"Chromosomally healthy\" embryos are then transferred into the mother's uterus, significantly increasing the chances of achieving pregnancy and giving birth to a healthy child.<\/p>\n\n

INDICATIONS FOR TESTING:<\/h3>\n\n


\n\u2022 Repeated miscarriages (2 times or more).
\n\u2022 Birth or miscarriage of a fetus with chromosomal abnormality.
\n\u2022 Repeated implantation failure after previous IVF cycles\/embryo transfers (2 times or more).
\n\u2022 Significantly impaired sperm parameters in the partner.
\n\u2022 Use of sperm after TESE (sperm retrieval directly from the testicle) or MESA (sperm retrieval from the epididymis) for IVF.
\n\u2022 Condition after treatment of oncological disease with chemotherapy or radiation in one or both partners.<\/p>\n\n

In addition to the main indications mentioned above, PGT-A can be performed as part of any IVF-ICSI cycle to increase the chances of achieving pregnancy and giving birth to a healthy child (in a self-paying regime).<\/p>\n\n

TESTING METHODS:<\/h3>\n\n

Currently, we perform PGS (PGT-A) using next-generation sequencing (NGS)<\/a><\/strong> or fluorescence in situ hybridization (FISH)<\/a><\/strong>.<\/p>\n\n

PGS (PGT-A) using next-generation sequencing (NGS) allows for the examination of more extensive quantitative changes (gains or losses) of genetic material across the entire genome, i.e., all 24 chromosomes.<\/p>\n\n

PGS (PGT-A) using fluorescence in situ hybridization (FISH) is usually performed for only 5 chromosomes and is used exceptionally, according to the indication of the attending physician.<\/p>\n\n

TISSUES EXAMINED:<\/h3>\n\n

The examination is standardly performed on trophectoderm cells<\/strong> taken on the 5th-6th day of embryo development, but it can also be exceptionally performed on blastomeres<\/strong> or polar bodies <\/strong>(more detailed info under this link<\/a>).<\/p>\n\n

COURSE OF THERAPY:<\/h3>\n\n

If you decide to undergo therapy with preimplantation testing, its course will be similar to \"usual\" therapy with IVF-ICSI. The only difference will be that a biopsy will be performed on the embryo on the 5th-6th day of development \u2013 that is, the removal of several trophectoderm cells<\/a><\/strong>. This sample will then be tested in a genetic laboratory, and the biopsied embryos will be frozen. Once the test results are available, the IVF-ICSI cycle will continue with the transfer of a healthy embryo.<\/p>\n\n

see Course of therapy with preimplantation genetic testing<\/a><\/strong><\/p>\n\n

Examples of PGT-A results using the NGS method<\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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star\u0161\u00ed n\u00e1zev PGS: Preimplanta\u010dn\u00ed Genetick\u00fd Screening Preimplanta\u010dn\u00ed genetick\u00fd screening (PGS (PGT-A)) je vy\u0161et\u0159en\u00ed zam\u011b\u0159en\u00e9 na chromosomovou v\u00fdbavu embrya. Je toti\u017e zn\u00e1mo, \u017ee jednou z hlavn\u00edch p\u0159\u00ed\u010din poruch plodnosti u lid\u00ed je vznik embry\u00ed s abnorm\u00e1ln\u00ed chromosomovou sadou. Takov\u00e1 embrya bu\u010f v\u016fbec nevedou k t\u011bhotenstv\u00ed (neimplantuj\u00ed do d\u011blo\u017en\u00ed sliznice) nebo vedou k potrat\u016fm \u010di, v krajn\u00edm p\u0159\u00edpad\u011b, k narozen\u00ed posti\u017een\u00e9ho d\u00edt\u011bte. Pomoc\u00ed PGS (PGT-A) lze odli\u0161it embrya s norm\u00e1ln\u00edm chromosomov\u00fdm […]<\/p>","protected":false},"author":9,"featured_media":0,"parent":7368,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"service-area":[32],"class_list":["post-7722","page","type-page","status-publish","hentry","service-area-vysetreni-reprodukcni-genetiky"],"yoast_head":"\nPGT-A: Preimplanta\u010dn\u00ed Genetick\u00e9 testov\u00e1n\u00ed Aneuploidi\u00ed | Genetika Plze\u0148<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genetika-plzen.nullable.group\/en\/vysetreni-reprodukcni-genetiky\/pgt-a-preimplantacni-geneticke-testovani-aneuploidii\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PGT-A: Preimplanta\u010dn\u00ed Genetick\u00e9 testov\u00e1n\u00ed Aneuploidi\u00ed | Genetika Plze\u0148\" \/>\n<meta property=\"og:description\" content=\"star\u0161\u00ed n\u00e1zev PGS: Preimplanta\u010dn\u00ed Genetick\u00fd Screening Preimplanta\u010dn\u00ed genetick\u00fd screening (PGS (PGT-A)) je vy\u0161et\u0159en\u00ed zam\u011b\u0159en\u00e9 na chromosomovou v\u00fdbavu embrya. Je toti\u017e zn\u00e1mo, \u017ee jednou z hlavn\u00edch p\u0159\u00ed\u010din poruch plodnosti u lid\u00ed je vznik embry\u00ed s abnorm\u00e1ln\u00ed chromosomovou sadou. Takov\u00e1 embrya bu\u010f v\u016fbec nevedou k t\u011bhotenstv\u00ed (neimplantuj\u00ed do d\u011blo\u017en\u00ed sliznice) nebo vedou k potrat\u016fm \u010di, v krajn\u00edm p\u0159\u00edpad\u011b, k narozen\u00ed posti\u017een\u00e9ho d\u00edt\u011bte. 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