{"id":7806,"date":"2024-02-15T18:38:55","date_gmt":"2024-02-15T17:38:55","guid":{"rendered":"https:\/\/genetika-plzen.nullable.group\/?page_id=7806"},"modified":"2024-02-15T18:42:31","modified_gmt":"2024-02-15T17:42:31","slug":"pgt-sr-preimplantacni-geneticke-testovani-pro-familiarni-strukturni-chromosomovou-aberaci-prestavbu","status":"publish","type":"page","link":"https:\/\/genetika-plzen.nullable.group\/en\/vysetreni-reprodukcni-genetiky\/pgt-sr-preimplantacni-geneticke-testovani-pro-familiarni-strukturni-chromosomovou-aberaci-prestavbu\/","title":{"rendered":"PGT-SR: Preimplantation Genetic Testing for familial Structural chromosomal Rearrangements"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"7806\" class=\"elementor elementor-7806\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ba2f5f1 e-flex e-con-boxed e-con e-parent\" data-id=\"ba2f5f1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-93333f5 elementor-widget elementor-widget-spacer\" data-id=\"93333f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8680f80 e-flex e-con-boxed e-con e-parent\" data-id=\"8680f80\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-94d46c1 elementor-widget elementor-widget-text-editor\" data-id=\"94d46c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Former name PGD: Preimplantation Genetic Diagnosis for familial chromosomal aberration<\/h2>\n\n<p>Preimplantation genetic testing for familial chromosomal aberrations\/rearrangements (PGT-SR) is a targeted diagnosis of unbalanced forms of specific familial chromosomal abnormalities that may lead to the birth of a child with disabilities or recurrent pregnancy losses. This examination is always conducted based on the indication of a clinical geneticist after evaluating the family history.<\/p>\n\n<h3>INDICATIONS FOR TESTING:<\/h3>\n\n<p>\u2022 Carrier of so-called balanced chromosomal rearrangement (usually translocation) in one or both partners.<br>\n\u2022 Presence of numerical changes in sex chromosomes (gonosomes), including mosaic forms, in one or both partners.<\/p>\n\n<h3>TESTING METHODS:<\/h3>\n\n<p>Currently, we perform PGT-SR <strong><a href=\"https:\/\/genetika-plzen.nullable.group\/en\/vysetreni-reprodukcni-genetiky\/ngs-sekvenovani-nove-generace\/\">using next-generation sequencing (NGS)<\/a><\/strong> or&nbsp;<strong><a href=\"https:\/\/genetika-plzen.nullable.group\/en\/vysetreni-reprodukcni-genetiky\/fish-fluorescencni-in-situ-hybridizace\/\">fluorescence in situ hybridization (FISH)<\/a><\/strong>.<\/p>\n\n<p>PGT-SR using NGS allows for the examination of unbalanced forms of familial chromosomal rearrangements of larger extent and simultaneous screening for quantitative changes in other chromosomes (PGT-A).<\/p>\n\n<p>PGT-SR using FISH is used only for PGT-SR of unbalanced forms of familial structural rearrangements of small extent, where NGS cannot be used.<\/p>\n\n<h3>TISSUES EXAMINED:<\/h3>\n\n<p>The examination is standardly performed <strong>on trophectoderm cells<\/strong> taken on the 5th-6th day of embryo development, but it can also be exceptionally performed on&nbsp;<strong>blastomeres&nbsp;<\/strong>or&nbsp;<strong>polar bodies <\/strong>(more detailed info under&nbsp;<a href=\"https:\/\/genetika-plzen.nullable.group\/en\/vysetreni-reprodukcni-genetiky\/vysetrovane-tkane\/\">this link<\/a>).<\/p>\n\n<h3>COURSE OF THERAPY:<\/h3>\n\n<p>If you decide to undergo therapy with preimplantation testing, its course will be similar to \"usual\" therapy with IVF-ICSI. The only difference will be that a biopsy will be performed on the embryo on the 5th-6th day of development \u2013 that is, the <a href=\"https:\/\/genetika-plzen.nullable.group\/en\/vysetreni-reprodukcni-genetiky\/vysetrovane-tkane\/\"><strong>removal of several trophectoderm cells<\/strong><\/a>. This sample will then be tested in a genetic laboratory, and the biopsied embryos will be frozen. Once the test results are available, the IVF-ICSI cycle will continue with the transfer of a healthy embryo.<\/p>\n\n<p>see <strong><a href=\"https:\/\/genetika-plzen.nullable.group\/en\/vysetreni-reprodukcni-genetiky\/prubeh-terapie-s-preimplantacnim-genetickym-vysetrenim\/\">Course of therapy with preimplantation genetic testing<\/a><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8e33e5f e-flex e-con-boxed e-con e-parent\" data-id=\"8e33e5f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d8a69f4 elementor-widget elementor-widget-image\" data-id=\"d8a69f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"650\" height=\"435\" src=\"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/PGT_SR.png\" class=\"attachment-large size-large wp-image-7817\" alt=\"\" srcset=\"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/PGT_SR.png 650w, https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/PGT_SR-300x201.png 300w, https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/PGT_SR-18x12.png 18w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a362f00 elementor-widget elementor-widget-image\" data-id=\"a362f00\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"556\" height=\"324\" src=\"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/priklad_PGT_SR.png\" class=\"attachment-large size-large wp-image-7818\" alt=\"\" srcset=\"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/priklad_PGT_SR.png 556w, https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/priklad_PGT_SR-300x175.png 300w, https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/priklad_PGT_SR-18x10.png 18w\" sizes=\"(max-width: 556px) 100vw, 556px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e84cdb7 elementor-widget elementor-widget-spacer\" data-id=\"e84cdb7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>star\u0161\u00ed n\u00e1zev PGD:&nbsp;Preimplanta\u010dn\u00ed Genetick\u00e1 Diagnostika famili\u00e1rn\u00ed chromosomov\u00e9 aberace) Preimplata\u010dn\u00ed genetick\u00e9 testov\u00e1n\u00ed famili\u00e1rn\u00edch chromosomov\u00fdch aberac\u00ed\/p\u0159estaveb (PGT-SR) je c\u00edlen\u00e1 diagnostika nebalancovan\u00fdch forem konkr\u00e9tn\u00edch famili\u00e1rn\u00edch chromosomov\u00fdch abnormalit, kter\u00e9 mohou v\u00e9st k&nbsp;narozen\u00ed posti\u017een\u00e9ho d\u00edt\u011bte nebo&nbsp;k&nbsp;opakuj\u00edc\u00edm se&nbsp;t\u011bhotensk\u00fdm ztr\u00e1t\u00e1m. Toto vy\u0161et\u0159en\u00ed je v\u017edy prov\u00e1d\u011bno na&nbsp;z\u00e1klad\u011b indikace klinick\u00e9ho genetika po&nbsp;zhodnocen\u00ed rodinn\u00e9 anamn\u00e9zy. INDIKACE K&nbsp;VY\u0160ET\u0158EN\u00cd \u2022 Nosi\u010dstv\u00ed tzv. balancovan\u00e9 chromosomov\u00e9 p\u0159estavby (obvykle translokace) [&hellip;]<\/p>","protected":false},"author":9,"featured_media":0,"parent":7368,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"service-area":[32],"class_list":["post-7806","page","type-page","status-publish","hentry","service-area-vysetreni-reprodukcni-genetiky"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>PGT-SR: Preimplanta\u010dn\u00ed Genetick\u00e9 Testov\u00e1n\u00ed pro famili\u00e1rn\u00ed Strukturn\u00ed chromosomovou aberaci\/p\u0159estavbu | Genetika Plze\u0148<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genetika-plzen.nullable.group\/en\/vysetreni-reprodukcni-genetiky\/pgt-sr-preimplantacni-geneticke-testovani-pro-familiarni-strukturni-chromosomovou-aberaci-prestavbu\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PGT-SR: Preimplanta\u010dn\u00ed Genetick\u00e9 Testov\u00e1n\u00ed pro famili\u00e1rn\u00ed Strukturn\u00ed chromosomovou aberaci\/p\u0159estavbu | Genetika Plze\u0148\" \/>\n<meta property=\"og:description\" content=\"star\u0161\u00ed n\u00e1zev PGD:&nbsp;Preimplanta\u010dn\u00ed Genetick\u00e1 Diagnostika famili\u00e1rn\u00ed chromosomov\u00e9 aberace) Preimplata\u010dn\u00ed genetick\u00e9 testov\u00e1n\u00ed famili\u00e1rn\u00edch chromosomov\u00fdch aberac\u00ed\/p\u0159estaveb (PGT-SR) je c\u00edlen\u00e1 diagnostika nebalancovan\u00fdch forem konkr\u00e9tn\u00edch famili\u00e1rn\u00edch chromosomov\u00fdch abnormalit, kter\u00e9 mohou v\u00e9st k&nbsp;narozen\u00ed posti\u017een\u00e9ho d\u00edt\u011bte nebo&nbsp;k&nbsp;opakuj\u00edc\u00edm se&nbsp;t\u011bhotensk\u00fdm ztr\u00e1t\u00e1m. Toto vy\u0161et\u0159en\u00ed je v\u017edy prov\u00e1d\u011bno na&nbsp;z\u00e1klad\u011b indikace klinick\u00e9ho genetika po&nbsp;zhodnocen\u00ed rodinn\u00e9 anamn\u00e9zy. INDIKACE K&nbsp;VY\u0160ET\u0158EN\u00cd \u2022 Nosi\u010dstv\u00ed tzv. balancovan\u00e9 chromosomov\u00e9 p\u0159estavby (obvykle translokace) [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/genetika-plzen.nullable.group\/en\/vysetreni-reprodukcni-genetiky\/pgt-sr-preimplantacni-geneticke-testovani-pro-familiarni-strukturni-chromosomovou-aberaci-prestavbu\/\" \/>\n<meta property=\"og:site_name\" content=\"Genetika Plze\u0148\" \/>\n<meta property=\"article:modified_time\" content=\"2024-02-15T17:42:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/PGT_SR.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" 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Plze\u0148","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/genetika-plzen.nullable.group\/en\/vysetreni-reprodukcni-genetiky\/pgt-sr-preimplantacni-geneticke-testovani-pro-familiarni-strukturni-chromosomovou-aberaci-prestavbu\/","og_locale":"en_GB","og_type":"article","og_title":"PGT-SR: Preimplanta\u010dn\u00ed Genetick\u00e9 Testov\u00e1n\u00ed pro famili\u00e1rn\u00ed Strukturn\u00ed chromosomovou aberaci\/p\u0159estavbu | Genetika Plze\u0148","og_description":"star\u0161\u00ed n\u00e1zev PGD:&nbsp;Preimplanta\u010dn\u00ed Genetick\u00e1 Diagnostika famili\u00e1rn\u00ed chromosomov\u00e9 aberace) Preimplata\u010dn\u00ed genetick\u00e9 testov\u00e1n\u00ed famili\u00e1rn\u00edch chromosomov\u00fdch aberac\u00ed\/p\u0159estaveb (PGT-SR) je c\u00edlen\u00e1 diagnostika nebalancovan\u00fdch forem konkr\u00e9tn\u00edch famili\u00e1rn\u00edch chromosomov\u00fdch abnormalit, kter\u00e9 mohou v\u00e9st k&nbsp;narozen\u00ed posti\u017een\u00e9ho d\u00edt\u011bte nebo&nbsp;k&nbsp;opakuj\u00edc\u00edm se&nbsp;t\u011bhotensk\u00fdm ztr\u00e1t\u00e1m. Toto vy\u0161et\u0159en\u00ed je v\u017edy prov\u00e1d\u011bno na&nbsp;z\u00e1klad\u011b indikace klinick\u00e9ho genetika po&nbsp;zhodnocen\u00ed rodinn\u00e9 anamn\u00e9zy. INDIKACE K&nbsp;VY\u0160ET\u0158EN\u00cd \u2022 Nosi\u010dstv\u00ed tzv. balancovan\u00e9 chromosomov\u00e9 p\u0159estavby (obvykle translokace) [&hellip;]","og_url":"https:\/\/genetika-plzen.nullable.group\/en\/vysetreni-reprodukcni-genetiky\/pgt-sr-preimplantacni-geneticke-testovani-pro-familiarni-strukturni-chromosomovou-aberaci-prestavbu\/","og_site_name":"Genetika Plze\u0148","article_modified_time":"2024-02-15T17:42:31+00:00","og_image":[{"url":"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/PGT_SR.png"}],"twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/genetika-plzen.nullable.group\/vysetreni-reprodukcni-genetiky\/pgt-sr-preimplantacni-geneticke-testovani-pro-familiarni-strukturni-chromosomovou-aberaci-prestavbu\/","url":"https:\/\/genetika-plzen.nullable.group\/vysetreni-reprodukcni-genetiky\/pgt-sr-preimplantacni-geneticke-testovani-pro-familiarni-strukturni-chromosomovou-aberaci-prestavbu\/","name":"PGT-SR: Preimplanta\u010dn\u00ed Genetick\u00e9 Testov\u00e1n\u00ed pro famili\u00e1rn\u00ed Strukturn\u00ed chromosomovou aberaci\/p\u0159estavbu | Genetika Plze\u0148","isPartOf":{"@id":"https:\/\/genetika-plzen.nullable.group\/#website"},"datePublished":"2024-02-15T17:38:55+00:00","dateModified":"2024-02-15T17:42:31+00:00","breadcrumb":{"@id":"https:\/\/genetika-plzen.nullable.group\/vysetreni-reprodukcni-genetiky\/pgt-sr-preimplantacni-geneticke-testovani-pro-familiarni-strukturni-chromosomovou-aberaci-prestavbu\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/genetika-plzen.nullable.group\/vysetreni-reprodukcni-genetiky\/pgt-sr-preimplantacni-geneticke-testovani-pro-familiarni-strukturni-chromosomovou-aberaci-prestavbu\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/genetika-plzen.nullable.group\/vysetreni-reprodukcni-genetiky\/pgt-sr-preimplantacni-geneticke-testovani-pro-familiarni-strukturni-chromosomovou-aberaci-prestavbu\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/genetika-plzen.nullable.group\/"},{"@type":"ListItem","position":2,"name":"Vy\u0161et\u0159en\u00ed reproduk\u010dn\u00ed genetiky","item":"https:\/\/genetika-plzen.nullable.group\/vysetreni-reprodukcni-genetiky\/"},{"@type":"ListItem","position":3,"name":"PGT-SR: Preimplanta\u010dn\u00ed Genetick\u00e9 Testov\u00e1n\u00ed pro famili\u00e1rn\u00ed Strukturn\u00ed chromosomovou aberaci\/p\u0159estavbu"}]},{"@type":"WebSite","@id":"https:\/\/genetika-plzen.nullable.group\/#website","url":"https:\/\/genetika-plzen.nullable.group\/","name":"Genetika Plze\u0148","description":"Genetika Plze\u0148","publisher":{"@id":"https:\/\/genetika-plzen.nullable.group\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/genetika-plzen.nullable.group\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/genetika-plzen.nullable.group\/#organization","name":"Genetika Plze\u0148","url":"https:\/\/genetika-plzen.nullable.group\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/genetika-plzen.nullable.group\/#\/schema\/logo\/image\/","url":"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2022\/07\/logo2.svg","contentUrl":"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2022\/07\/logo2.svg","width":286,"height":95,"caption":"Genetika Plze\u0148"},"image":{"@id":"https:\/\/genetika-plzen.nullable.group\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/genetika-plzen.nullable.group\/en\/wp-json\/wp\/v2\/pages\/7806","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/genetika-plzen.nullable.group\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/genetika-plzen.nullable.group\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/genetika-plzen.nullable.group\/en\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/genetika-plzen.nullable.group\/en\/wp-json\/wp\/v2\/comments?post=7806"}],"version-history":[{"count":10,"href":"https:\/\/genetika-plzen.nullable.group\/en\/wp-json\/wp\/v2\/pages\/7806\/revisions"}],"predecessor-version":[{"id":7821,"href":"https:\/\/genetika-plzen.nullable.group\/en\/wp-json\/wp\/v2\/pages\/7806\/revisions\/7821"}],"up":[{"embeddable":true,"href":"https:\/\/genetika-plzen.nullable.group\/en\/wp-json\/wp\/v2\/pages\/7368"}],"wp:attachment":[{"href":"https:\/\/genetika-plzen.nullable.group\/en\/wp-json\/wp\/v2\/media?parent=7806"}],"wp:term":[{"taxonomy":"service-area","embeddable":true,"href":"https:\/\/genetika-plzen.nullable.group\/en\/wp-json\/wp\/v2\/service-area?post=7806"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}