{"id":7875,"date":"2024-02-15T22:43:23","date_gmt":"2024-02-15T21:43:23","guid":{"rendered":"https:\/\/genetika-plzen.nullable.group\/?page_id=7875"},"modified":"2024-02-29T19:45:38","modified_gmt":"2024-02-29T18:45:38","slug":"fish-analyza-chromosovych-aberaci","status":"publish","type":"page","link":"https:\/\/genetika-plzen.nullable.group\/en\/cytogeneticka-laborator\/fish-analyza-chromosovych-aberaci\/","title":{"rendered":"FISH Analysis of Chromosomal Aberrations"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"7875\" class=\"elementor elementor-7875\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e908305 e-flex e-con-boxed e-con e-parent\" data-id=\"e908305\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f2c9928 elementor-widget elementor-widget-spacer\" data-id=\"f2c9928\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6eddbca e-flex e-con-boxed e-con e-parent\" data-id=\"6eddbca\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-77c5f2f elementor-widget elementor-widget-text-editor\" data-id=\"77c5f2f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>FISH is a microscopic molecular-cytogenetic method that allows targeted examination of predetermined chromosomal regions\/genes. In our laboratory, FISH examination is a supplementary test that specifies and\/or confirms an individual's karyotype.<\/p>\n<p>Principle of the FISH Method: The examined metaphases and\/or cell nuclei are fixed on a microscope slide. The principle of the method involves labeling several specific chromosomal regions with a fluorescently labeled probe complementary to the given DNA segment. Evaluation is performed using fluorescence microscopy. The method can only determine changes in selected chromosomes or their parts, marked by the chosen fluorescent probe.<\/p>\n<p>Example of confirming reciprocal translocation with painting probes:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b462362 elementor-widget elementor-widget-image\" data-id=\"b462362\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"694\" src=\"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/DOBISOVA-IVETA.009.A-1024x888.jpg\" class=\"attachment-large size-large wp-image-8422\" alt=\"\" srcset=\"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/DOBISOVA-IVETA.009.A-1024x888.jpg 1024w, https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/DOBISOVA-IVETA.009.A-300x260.jpg 300w, https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/DOBISOVA-IVETA.009.A-768x666.jpg 768w, https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/DOBISOVA-IVETA.009.A-14x12.jpg 14w, https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/DOBISOVA-IVETA.009.A.jpg 1103w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1be6fb0 e-flex e-con-boxed e-con e-parent\" data-id=\"1be6fb0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c2501ab elementor-widget elementor-widget-text-editor\" data-id=\"c2501ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Example of elucidating a structural aberration with locus-specific probes \u2013 isodicentric chromosome<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-45b0074 e-flex e-con-boxed e-con e-parent\" data-id=\"45b0074\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e399077 elementor-widget elementor-widget-image\" data-id=\"e399077\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"694\" src=\"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/STREITOVA-ZUZANA.027.A-1024x888.jpg\" class=\"attachment-large size-large wp-image-8423\" alt=\"\" srcset=\"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/STREITOVA-ZUZANA.027.A-1024x888.jpg 1024w, https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/STREITOVA-ZUZANA.027.A-300x260.jpg 300w, https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/STREITOVA-ZUZANA.027.A-768x666.jpg 768w, https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/STREITOVA-ZUZANA.027.A-14x12.jpg 14w, https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/STREITOVA-ZUZANA.027.A.jpg 1103w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-561992c e-flex e-con-boxed e-con e-parent\" data-id=\"561992c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aecb8cb elementor-widget elementor-widget-spacer\" data-id=\"aecb8cb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>FISH je mikroskopick\u00e1 molekul\u00e1rn\u011b-cytogenetick\u00e1 metoda umo\u017e\u0148uj\u00edc\u00ed c\u00edlen\u00e9 vy\u0161et\u0159en\u00ed p\u0159edem ur\u010den\u00fdch chromosomov\u00fdch oblast\u00ed\/gen\u016f. Vy\u0161et\u0159en\u00ed metodou FISH je v\u00a0na\u0161\u00ed laborato\u0159i dopl\u0148uj\u00edc\u00edm vy\u0161et\u0159en\u00edm, kter\u00e9 up\u0159es\u0148uje a\/nebo potvrzuje karyotyp jedince. Princip metody FISH:\u00a0Vy\u0161et\u0159ovan\u00e9 jsou metaf\u00e1ze a\/nebo bun\u011b\u010dn\u00e1 j\u00e1dra fixovan\u00e1 na\u00a0podlo\u017en\u00ed mikroskopick\u00e9 sklo. Principem metody je ozna\u010den\u00ed n\u011bkolika specifick\u00fdch chromosomov\u00fdch oblast\u00ed fluorescen\u010dn\u011b zna\u010denou sondou komplement\u00e1rn\u00ed k\u00a0dan\u00e9mu \u00faseku DNA.\u00a0Vyhodnocen\u00ed je prov\u00e1d\u011bno [&hellip;]<\/p>","protected":false},"author":9,"featured_media":0,"parent":7189,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"service-area":[28],"class_list":["post-7875","page","type-page","status-publish","hentry","service-area-cytogeneticka-laborator"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>FISH anal\u00fdza chromosomov\u00fdch aberac\u00ed | Genetika Plze\u0148<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genetika-plzen.nullable.group\/en\/cytogeneticka-laborator\/fish-analyza-chromosovych-aberaci\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FISH anal\u00fdza chromosomov\u00fdch aberac\u00ed | Genetika Plze\u0148\" \/>\n<meta property=\"og:description\" content=\"FISH je mikroskopick\u00e1 molekul\u00e1rn\u011b-cytogenetick\u00e1 metoda umo\u017e\u0148uj\u00edc\u00ed c\u00edlen\u00e9 vy\u0161et\u0159en\u00ed p\u0159edem ur\u010den\u00fdch chromosomov\u00fdch oblast\u00ed\/gen\u016f. Vy\u0161et\u0159en\u00ed metodou FISH je v\u00a0na\u0161\u00ed laborato\u0159i dopl\u0148uj\u00edc\u00edm vy\u0161et\u0159en\u00edm, kter\u00e9 up\u0159es\u0148uje a\/nebo potvrzuje karyotyp jedince. Princip metody FISH:\u00a0Vy\u0161et\u0159ovan\u00e9 jsou metaf\u00e1ze a\/nebo bun\u011b\u010dn\u00e1 j\u00e1dra fixovan\u00e1 na\u00a0podlo\u017en\u00ed mikroskopick\u00e9 sklo. Principem metody je ozna\u010den\u00ed n\u011bkolika specifick\u00fdch chromosomov\u00fdch oblast\u00ed fluorescen\u010dn\u011b zna\u010denou sondou komplement\u00e1rn\u00ed k\u00a0dan\u00e9mu \u00faseku DNA.\u00a0Vyhodnocen\u00ed je prov\u00e1d\u011bno [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/genetika-plzen.nullable.group\/en\/cytogeneticka-laborator\/fish-analyza-chromosovych-aberaci\/\" \/>\n<meta property=\"og:site_name\" content=\"Genetika Plze\u0148\" \/>\n<meta property=\"article:modified_time\" content=\"2024-02-29T18:45:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2024\/02\/DOBISOVA-IVETA.009.A-1024x888.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/genetika-plzen.nullable.group\/cytogeneticka-laborator\/fish-analyza-chromosovych-aberaci\/\",\"url\":\"https:\/\/genetika-plzen.nullable.group\/cytogeneticka-laborator\/fish-analyza-chromosovych-aberaci\/\",\"name\":\"FISH anal\u00fdza chromosomov\u00fdch aberac\u00ed | Genetika Plze\u0148\",\"isPartOf\":{\"@id\":\"https:\/\/genetika-plzen.nullable.group\/#website\"},\"datePublished\":\"2024-02-15T21:43:23+00:00\",\"dateModified\":\"2024-02-29T18:45:38+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/genetika-plzen.nullable.group\/cytogeneticka-laborator\/fish-analyza-chromosovych-aberaci\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/genetika-plzen.nullable.group\/cytogeneticka-laborator\/fish-analyza-chromosovych-aberaci\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/genetika-plzen.nullable.group\/cytogeneticka-laborator\/fish-analyza-chromosovych-aberaci\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/genetika-plzen.nullable.group\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Cytogenetick\u00e1 laborato\u0159\",\"item\":\"https:\/\/genetika-plzen.nullable.group\/cytogeneticka-laborator\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"FISH anal\u00fdza chromosomov\u00fdch aberac\u00ed\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/genetika-plzen.nullable.group\/#website\",\"url\":\"https:\/\/genetika-plzen.nullable.group\/\",\"name\":\"Genetika Plze\u0148\",\"description\":\"Genetika Plze\u0148\",\"publisher\":{\"@id\":\"https:\/\/genetika-plzen.nullable.group\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/genetika-plzen.nullable.group\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/genetika-plzen.nullable.group\/#organization\",\"name\":\"Genetika Plze\u0148\",\"url\":\"https:\/\/genetika-plzen.nullable.group\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/genetika-plzen.nullable.group\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2022\/07\/logo2.svg\",\"contentUrl\":\"https:\/\/genetika-plzen.nullable.group\/wp-content\/uploads\/2022\/07\/logo2.svg\",\"width\":286,\"height\":95,\"caption\":\"Genetika Plze\u0148\"},\"image\":{\"@id\":\"https:\/\/genetika-plzen.nullable.group\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"FISH anal\u00fdza chromosomov\u00fdch aberac\u00ed | Genetika Plze\u0148","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/genetika-plzen.nullable.group\/en\/cytogeneticka-laborator\/fish-analyza-chromosovych-aberaci\/","og_locale":"en_GB","og_type":"article","og_title":"FISH anal\u00fdza chromosomov\u00fdch aberac\u00ed | Genetika Plze\u0148","og_description":"FISH je mikroskopick\u00e1 molekul\u00e1rn\u011b-cytogenetick\u00e1 metoda umo\u017e\u0148uj\u00edc\u00ed c\u00edlen\u00e9 vy\u0161et\u0159en\u00ed p\u0159edem ur\u010den\u00fdch chromosomov\u00fdch oblast\u00ed\/gen\u016f. Vy\u0161et\u0159en\u00ed metodou FISH je v\u00a0na\u0161\u00ed laborato\u0159i dopl\u0148uj\u00edc\u00edm vy\u0161et\u0159en\u00edm, kter\u00e9 up\u0159es\u0148uje a\/nebo potvrzuje karyotyp jedince. Princip metody FISH:\u00a0Vy\u0161et\u0159ovan\u00e9 jsou metaf\u00e1ze a\/nebo bun\u011b\u010dn\u00e1 j\u00e1dra fixovan\u00e1 na\u00a0podlo\u017en\u00ed mikroskopick\u00e9 sklo. 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