{"id":8001,"date":"2024-02-16T00:17:22","date_gmt":"2024-02-15T23:17:22","guid":{"rendered":"https:\/\/genetika-plzen.nullable.group\/?page_id=8001"},"modified":"2024-04-24T00:08:11","modified_gmt":"2024-04-23T22:08:11","slug":"nipt","status":"publish","type":"page","link":"https:\/\/genetika-plzen.nullable.group\/en\/geneticka-ambulance\/nipt\/","title":{"rendered":"NIPT"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"8001\" class=\"elementor elementor-8001\">\n\t\t\t\t<div class=\"elementor-element elementor-element-944f8fb e-flex e-con-boxed e-con e-parent\" data-id=\"944f8fb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8337b2d elementor-widget elementor-widget-spacer\" data-id=\"8337b2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-08d182e e-flex e-con-boxed e-con e-parent\" data-id=\"08d182e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2b79494 elementor-widget elementor-widget-text-editor\" data-id=\"2b79494\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\" translation-block\"><p>NIPT stands for non-invasive prenatal testing (screening) that examines cell-free fetal DNA (cffDNA) in mother\u2019s blood without need of sampling through the abdominal wall to obtain DNA.\u00a0It represents a non-invasive alternative to amniocentesis (amniotic fluid sampling) or chorionic villus sampling (CVS). The company Genetika Plze\u0148 in cooperation with Bioptick\u00e1 laborato\u0159, s.r.o. uses the PANORAMA test that allows detection of the most common chromosomal aberrations of the fetus: the Down syndrome - trisomy of chromosome 21 (supernumerary chromosome 21), Edwards syndrome - trisomy of chromosome 18 (supernumerary chromosome 18) and Patau syndrome - trisomy of chromosome 13 (supernumerary chromosome 13), and aneuploidy of chromosomes X and Y. Chromosomal aberrations are manifested by a specific appearance, intellectual disability and multiple organ defects. Treatment of chromosomal disorders is currently unavailable. The sex of the fetus is determined by detecting the presence of the Y chromosome. The patient will not be informed of the fetus sex until after 12 weeks of fetus gestation.<\/p>\n<p>The test requires about 20ml of blood that is collected by needle puncture after disinfection of the puncture site.<\/p>\n<p>Prenatal non-invasive testing is free from the risk of spontaneous abortion or infection and is highly accurate. The result of the examination will be made available within three weeks after sample receipt.<\/p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-225ff9b elementor-button-info elementor-widget elementor-widget-button\" data-id=\"225ff9b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/wp-content\/uploads\/2024\/02\/fgp_915_v002_nipt_dotaznik.pdf\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Requisition form<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e88d4e8 elementor-button-info elementor-widget elementor-widget-button\" data-id=\"e88d4e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/wp-content\/uploads\/2024\/06\/F.GP-914-v002-EN-Informed-consent-with-NIPT_interactive.pdf\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Informed consent<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8c895bc e-flex e-con-boxed e-con e-parent\" data-id=\"8c895bc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-32d1a53 elementor-widget elementor-widget-heading\" data-id=\"32d1a53\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">RISKS OF THE PROCEDURE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f9e25c2 e-flex e-con-boxed e-con e-parent\" data-id=\"f9e25c2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ab1459f elementor-widget elementor-widget-text-editor\" data-id=\"ab1459f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>During blood collection, it is very rare, but a bruise or inflammation may occur at the needle puncture site. Although the latest published data confirmed the sensitivity of this test for trisomy of chromosome 21 at 99%, trisomy of chromosome 18 at 96.4%, trisomy of chromosome 13 at 99%, and monosomy of chromosome X at 92.9%, it cannot yet be considered a diagnostic test, but only a highly effective screening test. Therefore, in the case of a positive finding of fetal impairment, the result must be verified by invasive examination of chorionic villi (CVS) or amniotic fluid (AMC), while a normal test result cannot completely rule out fetal impairment. This is due to the limitations of current technology.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8bc749a e-flex e-con-boxed e-con e-parent\" data-id=\"8bc749a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4bb793d elementor-widget elementor-widget-heading\" data-id=\"4bb793d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">LIMITATIONS OF PANORAMA TEST<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a17786d e-flex e-con-boxed e-con e-parent\" data-id=\"a17786d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-366a93e elementor-widget elementor-widget-text-editor\" data-id=\"366a93e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The test cannot be performed in the following instances:<\/p>\n\n<ul>\n  <li>in pregnant women who have undergone a bone marrow transplant<\/li><li>in pregnant women who have undergone blood transfusion within the last six months<\/li><li>if the fetal fraction is less than 2.8%<\/li><li>before the eight weeks of gestation <\/li><li>in case of gestational obesity if BMI&gt;35<\/li>\n<\/ul>  \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-02d63af e-flex e-con-boxed e-con e-parent\" data-id=\"02d63af\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-93099e4 elementor-widget elementor-widget-heading\" data-id=\"93099e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">PRICE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-edf7743 e-flex e-con-boxed e-con e-parent\" data-id=\"edf7743\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4d1a06c elementor-widget elementor-widget-text-editor\" data-id=\"4d1a06c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>NIPT is not covered by public healthcare insurance, the price for a patient is 12.500 CZK (see the price list <strong><a href=\"https:\/\/genetika-plzen.nullable.group\/en\/cenik\/#screeningy-v-tehotenstvi\">here<\/a><\/strong>).<br><br>The fee for NIPT will be refunded a) if the test is not concluded even after repeated (the second) sampling; b) if the result of the second sample is likely to be known after 24 weeks of gestation; or c) in case of a false-positive result.\n<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a37e871 e-flex e-con-boxed e-con e-parent\" data-id=\"a37e871\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8a82ad3 elementor-widget elementor-widget-spacer\" data-id=\"8a82ad3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>NIPT je zkratka pro neinvazivn\u00ed prenat\u00e1ln\u00ed testov\u00e1n\u00ed, n\u011bkdy se uv\u00e1d\u00ed screening. Neinvazivn\u00ed znamen\u00e1, \u017ee se testuje DNA plodu (voln\u00e1 fet\u00e1ln\u00ed DNA, cffDNA) z&nbsp;krve matky. Pro z\u00edsk\u00e1n\u00ed DNA nen\u00ed pot\u0159ebn\u00fd odb\u011br p\u0159es b\u0159i\u0161\u016fn\u00ed st\u011bnu (dutinu) jako u invazivn\u00edch metod, tedy biopsie choriov\u00fdch klk\u016f nebo aminocent\u00e9zy (odb\u011br plodov\u00e9 vody), kter\u00e9 jsou alternativou k tomuto vy\u0161et\u0159en\u00ed. Firma Genetika [&hellip;]<\/p>","protected":false},"author":9,"featured_media":0,"parent":7072,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"service-area":[27],"class_list":["post-8001","page","type-page","status-publish","hentry","service-area-geneticka-ambulance"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NIPT | Genetika Plze\u0148<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genetika-plzen.nullable.group\/en\/geneticka-ambulance\/nipt\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NIPT | Genetika Plze\u0148\" \/>\n<meta property=\"og:description\" content=\"NIPT je zkratka pro neinvazivn\u00ed prenat\u00e1ln\u00ed testov\u00e1n\u00ed, n\u011bkdy se uv\u00e1d\u00ed screening. Neinvazivn\u00ed znamen\u00e1, \u017ee se testuje DNA plodu (voln\u00e1 fet\u00e1ln\u00ed DNA, cffDNA) z&nbsp;krve matky. Pro z\u00edsk\u00e1n\u00ed DNA nen\u00ed pot\u0159ebn\u00fd odb\u011br p\u0159es b\u0159i\u0161\u016fn\u00ed st\u011bnu (dutinu) jako u invazivn\u00edch metod, tedy biopsie choriov\u00fdch klk\u016f nebo aminocent\u00e9zy (odb\u011br plodov\u00e9 vody), kter\u00e9 jsou alternativou k tomuto vy\u0161et\u0159en\u00ed. 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Neinvazivn\u00ed znamen\u00e1, \u017ee se testuje DNA plodu (voln\u00e1 fet\u00e1ln\u00ed DNA, cffDNA) z&nbsp;krve matky. Pro z\u00edsk\u00e1n\u00ed DNA nen\u00ed pot\u0159ebn\u00fd odb\u011br p\u0159es b\u0159i\u0161\u016fn\u00ed st\u011bnu (dutinu) jako u invazivn\u00edch metod, tedy biopsie choriov\u00fdch klk\u016f nebo aminocent\u00e9zy (odb\u011br plodov\u00e9 vody), kter\u00e9 jsou alternativou k tomuto vy\u0161et\u0159en\u00ed. 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